GRIN2A Antibody

Catalog Number:

40188

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q12879
Gene Accssion:NP_000824

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human glutamate receptor, ionotropic, N-methyl D-aspartate 2A

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total GRIN2A protein.

Applications:

IHC

Background:

This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants.

References:

appl_detail:

Immunohistochemistry:1:25-1:100

Datasheet PDF