RNF20 Antibody

Catalog Number:

40080

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q5VTR2
Gene Accssion:BC110585

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to residues near the C terminal of human ring finger protein 20, E3 ubiquitin protein ligase

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total RNF20 protein.

Applications:

WB IHC

Background:

The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor.

References:

appl_detail:

Western blotting: 1:500-1:2000
Immunohistochemistry:1:10-1:50

Datasheet PDF