PCNA Mouse Monoclonal Antibody

Catalog Number:

21801

Amount:

100μg

Price:

$529

Swiss-Prot No:

Swiss-Prot:P12004
Gene ID:5111

Form of Antibody:

Mouse IgG1 in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Mouse monoclonal antibody is prepared by immunizing a synthetic peptide.

Purification:

Affinity-chromatography

Specificity/Sensitivity:

Applications:

WB IHC

Background:

 PCNA is a marker for cells in early G1 phase and S phase of the cell cycle. It is found in the nucleus and is a cofactor of DNA polymerase delta. PCNA acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, PCNA is ubiquitinated and is involved in the RAD6 dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for PCNA. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.

References:

appl_detail:

 WB: 1:3000~1:10000   

 IHC: 1:200

 

Datasheet PDF