ORAI1 Monoclonal Antibody

Catalog Number:

26039

Amount:

100μg

Price:

$529

Swiss-Prot No:

Swiss-Prot:Q96D31
Gene ID:84876

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 16 amino acid peptide from near the carboxy terminus of human ORAI1.

Purification:

Immunoaffinity chromotography purified IgG

Specificity/Sensitivity:

Applications:

ELISA WB IHC

Background:

Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one fo rm of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE. This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.

References:

appl_detail:

Datasheet PDF