PD-1 Monoclonal Antibody

Catalog Number:

26034

Amount:

100μg

Price:

$529

Swiss-Prot No:

Swiss-Prot:Q02242
Gene ID:18566

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

A ~150 amino acid recombinant protein from near the terminus terminus of mouse PD-1.

Purification:

Immunoaffinity chromotography purified IgG

Specificity/Sensitivity:

Applications:

ELISA WB IHC

Background:

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.

References:

appl_detail:

Datasheet PDF