HSPB8 antibody

Catalog Number:

38413

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9UJY1
NCBI Gene ID: 26353

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Recombinant protein of human HSPB8.

Purification:

Antibodies were purified by affinity purification using immunogen.

Specificity/Sensitivity:

The antibody detects endogenous level of total HSPB8 antibody.

Applications:

WB IF

Background:

The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.

References:

appl_detail:

Western blotting: 1:500 - 1:2000
Immunofluorescence: 1:50 - 1:100

Datasheet PDF