PATE3 antibody

Catalog Number:

38398

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: B3GLJ2
NCBI Gene ID: 100169851

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Recombinant protein of human PATE3.

Purification:

Antibodies were purified by affinity purification using immunogen.

Specificity/Sensitivity:

The antibody detects endogenous level of total PATE3 antibody.

Applications:

WB

Background:

PATE3 (prostate and testis expressed protein 3), also known as PATE-DJ or HEL-127, is a 98 amino acid protein that contains one UPAR/Ly6 domain and belongs to the PATE family. PATE3 is a secreted protein that is expressed in prostate and testis. The gene that encodes PATE3 consists of around 3,490 bases and maps to human chromosome 11p15.5. Chromosome 11, which comprises approximately 4% of the human genome, is considered a gene and disease association-dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes.

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF