RASA2 Antibody

Catalog Number:

37861

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q15283
NCBI Gene ID: 5922
Gene Accssion: NP_006497/Q15283

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human RAS p21 protein activator 2

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total RASA2 protein.

Applications:

IHC

Background:

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member has a perinuclear localization and is an inositol 1,3,4,5-tetrakisphosphate-binding protein; a compound suggested to function as a second messenger.

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF