PHGDH Antibody

Catalog Number:

37821

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O43175
NCBI Gene ID: 26227
Gene Accssion: NP_006614

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human phosphoglycerate dehydrogenase

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total PHGDH protein.

Applications:

WB

Background:

This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known.

References:

appl_detail:

Western blotting: 1:200-1:1000

Datasheet PDF