RNLS Antibody

Catalog Number:

37867

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q5VYX0
NCBI Gene ID: 55328
Gene Accssion: NP_001026879/Q5VYX0

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human renalase, FAD-dependent amine oxidase

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total RNLS protein.

Applications:

WB

Background:

Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney. Catalyzes the oxidation of the less abundant alpha-NAD(P)H isoform toform beta-NAD(P)+. The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk.

References:

appl_detail:

Western blotting: 1:500-1:2000

Datasheet PDF