NPC1 Antibody

Catalog Number:

37774

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O15118
NCBI Gene ID: 4864
Gene Accssion: NP_000262

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human Niemann-Pick disease, type C1

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total NPC1 protein.

Applications:

IHC

Background:

This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol.?

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF