UHRF2 Antibody

Catalog Number:

37761

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q96PU4
NCBI Gene ID: 115426
Gene Accssion: NP_690856

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total UHRF2 protein.

Applications:

IHC

Background:

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding.

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF