SETD7 Antibody

Catalog Number:

36520

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q8WTS6
NCBI Gene ID: 80854
Gene Accssion: BC121055

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to residues near the C terminal of human SET domain containing (lysine methyltransferase) 7

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total SETD7 protein.

Applications:

IHC

Background:

The methylation of histones plays a pivotal role in the regulation of chromatin structure and gene expression. Histone methylation can occur on Arg or Lys residues, with an exquisite site selectivity for Lys methylation at specific positions in the N-termini of histones H3 and H4. SET7/9, a histone methyltransferase (HMTase), which transfers methyl groups to Lys4 of histone H3, forms a complex with S-adenosyl-L-methionine. This complex contains an active site consisting of a binding pocket where an AdoMet molecule in an unusual conformation binds, a narrow substrate-specific channel that only unmethylated lysine residues can access and a catalytic tyrosine residue.

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF