CENPC Antibody

Catalog Number:

36344

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q03188
NCBI Gene ID: 1060
Gene Accssion: BC030695

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to residues near the C terminal of human centromere protein C

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CENPC protein.

Applications:

IHC

Background:

Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF