IKZF3 Antibody

Catalog Number:

36254

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9UKT9
NCBI Gene ID: 22806
Gene Accssion: BC032707

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to residues near the C terminal of human IKAROS family zinc finger 3 (Aiolos)

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total IKZF3 protein.

Applications:

IHC

Background:

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF