PIM2 Antibody

Catalog Number:

36203

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9P1W9
NCBI Gene ID: 11040
Gene Accssion: BC018111

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from internal residues of human pim-2 oncogene

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total PIM2 protein.

Applications:

IHC

Background:

This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival. Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity.

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF