Stathmin1(Phospho-Ser38) Antibody

Catalog Number:

11225

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P16949
NCBI Protein: NP_001138926.1

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of serine 38 (P-L-S(p)-P-P) derived from Human Stathmin 1.

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Specificity/Sensitivity:

The antibody detects endogenous level of Stathmin 1 only when phosphorylated at serine 38.

Applications:

WB IHC

Background:

Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear

Wang KK, et al. (1991) Biochem J 279(Pt 2): 537-544.
Sekimoto T, et al. (2004) EMBO J 23(9): 1934-1942.
Doye V, et al. (1992) Biochem J 287(Pt 2): 549-554.
Larsson N, et al. (1999) Mol Cell Biol 19(3): 2242-2250.

References:

appl_detail:

Predicted MW: 19kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100

Datasheet PDF