SPDL1 Antibody

Catalog Number:

35932

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q96EA4
NCBI Gene ID: 54908
Gene Accssion: BC012568

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to residues near the C terminal of human Spindle apparatus coiled-coil protein 1

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total SPDL1 protein.

Applications:

WB

Background:

Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.

References:

appl_detail:

Western blotting: 1:500-1:2000

Datasheet PDF