COL1A2 Antibody

Catalog Number:

35634

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P08123
NCBI Gene ID: 1278
Gene Accssion: BC042586

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from internal residues of human collagen, type I, alpha 2

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total COL1A2 protein.

Applications:

IHC

Background:

This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.?

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF