ABL1 Antibody

Catalog Number:

35613

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P00519
NCBI Gene ID: 25
Gene Accssion: BC117451

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to residues near the C terminal of human c-abl oncogene 1, non-receptor tyrosine kinase

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total ABL1 protein.

Applications:

IHC

Background:

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.?

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF