BAG3 Antibody

Catalog Number:

35593

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O95817
NCBI Gene ID: 9531
Gene Accssion: BC014656

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to residues near the C terminal of human BCL2-associated athanogene 3

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total BAG3 protein.

Applications:

WB IHC

Background:

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.

References:

appl_detail:

Western blotting: 1:500-1:2000
Immunohistochemistry: 1:15-1:50

Datasheet PDF