CD79A Antibody

Catalog Number:

35306

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P11912
NCBI Gene ID: 973

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human CD79A.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CD79A protein.

Applications:

WB

Background:

Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.

Leduc I., Clin. Exp. Immunol. 90:141-146(1992).
Mueller B.S., Eur. J. Immunol. 22:1621-1625(1992).
Flaswinkel H., Immunogenetics 36:266-269(1992).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF