IFIT5 Antibody

Catalog Number:

35225

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q13325
NCBI Gene ID: 24138

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human IFIT5.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total IFIT5 protein.

Applications:

WB

Background:

Interferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and binds tRNAs.

Rogers J., Nature 429:375-381(2004).
Venter J.C., Submitted (SEP-2005).
Bennett K.L., Submitted (OCT-2008).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF