IL17RC Antibody

Catalog Number:

35223

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q8NAC3
NCBI Gene ID: 84818

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human IL17RC.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total IL17RC protein.

Applications:

WB

Background:

This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.

Gray A.M., Genome Res. 13:2265-2270(2003).
Gibbs R.A., Nature 440:1194-1198(2006).
Henzel W.J., Protein Sci. 13:2819-2824(2004).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF