GNE Antibody

Catalog Number:	35207
other_names:	Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; UDP-GlcNAc-2-epimerase/ManAc kinase; UDP-N-acetylglucosamine 2-epimerase; UDP-GlcNAc-2-epimerase; Uridine diphosphate-N-acetylglucosamine-2-epimeraseN-acetylmannosamine kinase
Amount:	100μg
calculated_mw:
host_species:	Rabbit
Price:	$319
Swiss-Prot No:	Swiss-Prot: Q9Y223 NCBI Gene ID: 10020
Form of Antibody:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage/Stability:
Immunogen:	Synthesized peptide derived from C-terminal of human GNE.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity/Sensitivity:	The antibody detects endogenous levels of total GNE protein.
Applications:	WB IHC
Background:	Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development By similarity. Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. Lucka L., FEBS Lett. 454:341-344(1999). Seppala R., Am. J. Hum. Genet. 64:1563-1569(1999). Huizing M., Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
References:
appl_detail:	Western blotting: 1:500~1:3000 Immunohistochemistry: 1:50~1:100
	Datasheet PDF

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