TAOK3 Antibody

Catalog Number:

35201

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9H2K8
NCBI Gene ID: 51347

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human TAOK3.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total TAOK3 protein.

Applications:

WB

Background:

Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).

Tassi E., J. Biol. Chem. 274:33287-33295(1999).
Zhang W., Biochem. Biophys. Res. Commun. 274:872-879(2000).
Yustein J.T., Oncogene 22:6129-6141(2003).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF