ELF4 Antibody

Catalog Number:

35197

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q99607
NCBI Gene ID: 2000

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human ELF4.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total ELF4 protein.

Applications:

WB

Background:

Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter By similarity. Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 By similarity. Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. UniProtKB Q9Z2U4

Miyazaki Y., Oncogene 13:1721-1729(1996).
Aryee D.N.T., Gene 210:71-78(1998).
Ross M.T., Nature 434:325-337(2005).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF