TEAD3 Antibody

Catalog Number:

35196

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q99594
NCBI Gene ID: 7005

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human TEAD3.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total TEAD3 protein.

Applications:

WB

Background:

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.

Jacquemin P., J. Biol. Chem. 272:12928-12937(1997).
Mungall A.J., Nature 425:805-811(2003).
Zhao B., Genes Dev. 22:1962-1971(2008).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF