CACNA1H Antibody

Catalog Number:

35145

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: O95180
NCBI Gene ID: 8912

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human CACNA1H.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CACNA1H protein.

Applications:

WB

Background:

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1Hgives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.

Cribbs L.L., Circ. Res. 83:103-109(1998).
Cribbs L.L., Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Williams M.E., J. Neurochem. 72:791-799(1999).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF