PTPN22 Antibody

Catalog Number:

35113

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9Y2R2
NCBI Gene ID: 26191

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from Internal of human PTPN22.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total PTPN22 protein.

Applications:

WB

Background:

Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2.

Cohen S., Blood 93:2013-2024(1999).
Liu T., Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
Wang S., Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF