TCF7L1 Antibody

Catalog Number:

35103

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9HCS4
NCBI Gene ID: 83439

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human TCF7L1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total TCF7L1 protein.

Applications:

WB

Background:

Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis By similarity. Down-regulates NQO1, leading to increased mitomycin c resistance.

Sagara N., Cancer Res. 60:5959-5962(2000).
Hillier L.W., Nature 434:724-731(2005).
Castrop J., Nucleic Acids Res. 20:611-611(1992).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF