UBASH3A Antibody

Catalog Number:

35080

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P57075
NCBI Gene ID: 53347

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human UBASH3A.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total UBASH3A protein.

Applications:

WB

Background:

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.

Wattenhofer M., Hum. Genet. 108:140-147(2001).
Feshchenko E.A., Oncogene 23:4690-4706(2004).
Hattori M., Nature 405:311-319(2000).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF