EWSR1 Antibody

Catalog Number:

35008

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q01844
NCBI Gene ID: 2130

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human EWSR1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total EWSR1 protein.

Applications:

WB

Background:

Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Delattre O., Nature 359:162-165(1992).
Plougastel B., Genomics 18:609-615(1993).
Zucman-Rossi J., Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF