ARHGEF1 Antibody

Catalog Number:

34990

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q92888
NCBI Gene ID: 9138

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human ARHGEF1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total ARHGEF1 protein.

Applications:

WB

Background:

Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.

Farmer A., Submitted (MAY-2003).
Wedegaertner P.B., J. Biol. Chem. 275:14992-14999(2000).
Han D.K., Sci. Signal. 2:RA46-RA46(2009).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF