RAB11FIP2 Antibody

Catalog Number:

34949

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q7L804
NCBI Gene ID: 22841

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human RAB11FIP2.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total RAB11FIP2 protein.

Applications:

WB

Background:

A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity.

Nagase T., DNA Res. 6:63-70(1999).
Prekeris R., Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
Deloukas P., Nature 429:375-381(2004).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF