PDK1 Antibody

Catalog Number:

34944

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q15118
NCBI Gene ID: 5163

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from Internal of human PDK1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total PDK1 protein.

Applications:

WB

Background:

Serine/threonine kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.

Gudi R., J. Biol. Chem. 270:28989-28994(1995).
Ota T., Nat. Genet. 36:40-45(2004).
Burkard T.R., BMC Syst. Biol. 5:17-17(2011).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF