KCNQ5 Antibody

Catalog Number:

34920

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9NR82
NCBI Gene ID: 56479

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human KCNQ5.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total KCNQ5 protein.

Applications:

WB

Background:

Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M1 muscarinic receptors.

Lerche C., J. Biol. Chem. 275:22395-22400(2000).
Mungall A.J., Nature 425:805-811(2003).
Schroeder B.C., J. Biol. Chem. 275:24089-24095(2000).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF