KCNA5 Antibody

Catalog Number:

34915

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P22460
NCBI Gene ID: 3741

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human KCNA5.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total KCNA5 protein.

Applications:

WB

Background:

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation.

Tamkun M.M., FASEB J. 5:331-337(1991).
Philipson L.H., Proc. Natl. Acad. Sci. U.S.A. 88:53-57(1991).
Curran M.E., Genomics 12:729-737(1992).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF