NUMA1 Antibody

Catalog Number:

34869

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q14980
NCBI Gene ID: 4926

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human NUMA1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total NUMA1 protein.

Applications:

WB IHC

Background:

Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions.

Yang C.H., J. Cell Biol. 116:1303-1317(1992).
Compton D.A., J. Cell Biol. 116:1395-1408(1992).
Maekawa T., J. Cell Sci. 105:589-600(1993).

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Datasheet PDF