PPP1R8 Antibody

Catalog Number:

34868

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q12972
NCBI Gene ID: 5511

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human PPP1R8.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total PPP1R8 protein.

Applications:

WB

Background:

Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation. Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform doesnot inhibit PP-1. May be implicated in mRNA splicing.

Wang M., Proc. Natl. Acad. Sci. U.S.A. 91:10591-10595(1994).
Van Eynde A., Eur. J. Biochem. 261:291-300(1999).
Liu J.P., Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF