SP100 Antibody

Catalog Number:

34867

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P23497
NCBI Gene ID: 6672

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from Internal of human SP100.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total SP100protein.

Applications:

WB

Background:

Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to . Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to . Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.

Dent A.L., Blood 88:1423-1426(1996).
Seeler J.-S., Proc. Natl. Acad. Sci. U.S.A. 95:7316-7321(1998).
Szostecki C., J. Immunol. 145:4338-4347(1990).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF