MPRIP Antibody

Catalog Number:

34818

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q6WCQ1
NCBI Gene ID: 23164

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human MPRIP.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total MPRIP protein.

Applications:

IHC

Background:

Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. UniProtKB P97434

Surks H.K., J. Biol. Chem. 278:51484-51493(2003).
Koga Y., J. Biol. Chem. 280:4983-4991(2005).
Inazawa J., Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.

References:

appl_detail:

Immunohistochemistry: 1:50~1:100

Datasheet PDF