MNDA Antibody

Catalog Number:

34813

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P41218
NCBI Gene ID: 4332

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from C-terminal of human MNDA.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total MNDA protein.

Applications:

WB

Background:

The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.

Briggs J.A., J. Cell. Biochem. 49:82-92(1992).
The MGC Project Team; Genome Res. 14:2121-2127(2004).
Burrus G.R., J. Cell. Biochem. 48:190-202(1992).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF