MSX2 Antibody

Catalog Number:

34744

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P35548
NCBI Gene ID: 4488

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from Internal of human MSX2.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total MSX2protein.

Applications:

WB

Background:

Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.

Hodgkinson J.E., Biochim. Biophys. Acta 1174:11-16(1993).
Jabs E.W., Cell 75:443-450(1993).
Iimura T., DNA Seq. 8:87-92(1997).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF