GNL3L Antibody

Catalog Number:

34732

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9NVN8
NCBI Gene ID: 54552

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human GNL3L.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total GNL3L protein.

Applications:

WB

Background:

Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.

Ota T., Nat. Genet. 36:40-45(2004).
Ross M.T., Nature 434:325-337(2005).
The MGC Project Team; Genome Res. 14-2121-2127(2004).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF