DKK3 Antibody

Catalog Number:

34645

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9UBP4
NCBI Gene ID: 27122

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human DKK3.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total DKK3 protein.

Applications:

WB

Background:

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease By similarity.

Shimizu K., Gene 282:151-158(2002).
Gray A.M., Genome Res. 13:2265-2270(2003).
Niehrs C., Oncogene 25:7469-7481(2006).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF