CXADR Antibody

Catalog Number:

34624

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P78310
NCBI Gene ID: 1525

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human CXADR.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CXADR protein.

Applications:

WB

Background:

Component of the epithelial apical junction complex that may function as an homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with AMICA1/JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.

Tomko R.P., Proc. Natl. Acad. Sci. U.S.A. 94:3352-3356(1997).
Bergelson J.M., Science 275:1320-1323(1997).
Bowles K.R., Hum. Genet. 105:354-359(1999).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF