CLIC4 Antibody

Catalog Number:

34584

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9Y696
NCBI Gene ID: 25932

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from N-terminal of human CLIC4.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CLIC4 protein.

Applications:

WB IHC

Background:

Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).

Wiemann S., Genome Res. 11:422-435(2001).
Edwards J.C.; Am. J. Physiol. 276:F398-F408(1999).
Chuang J.Z., J. Neurosci. 19:2919-2928(1999).

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Datasheet PDF