PARP3 Antibody

Catalog Number:

34293

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9Y6F1
NCBI Gene ID: 10039

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human PARP3.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total PARP3 protein.

Applications:

IHC

Background:

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.

Johansson M., Genomics 57:442-445(1999).
Augustin A., J. Cell Sci. 116:1551-1562(2003).
The MGC Project Team, Genome Res. 14:2121-2127(2004).

References:

appl_detail:

Immunohistochemistry: 1:50~1:100

Datasheet PDF