PARP2 Antibody

Catalog Number:

34292

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9UGN5
NCBI Gene ID: 10038

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human PARP2.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total PARP2 protein.

Applications:

WB

Background:

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.

Sugano S., Nat. Genet. 36:40-45(2004).
de Murcia G.M., J. Biol. Chem. 277:23028-23036(2002).
Bennett K.L., Submitted (OCT-2008).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF